THE NEUROLOGIC PAIN BLOG

Evidence-Based Insights for People With Complex & Persistent Pain


with Dr. Alissa Wolfe, PT, DPT, OMPT, OCS, CHC, TPS

Ice, Nerve Blocks, and Numbing Creams for CRPS: The Long-Term Downside of Numbing

central sensitization complex regional pain syndrome crps crps pain management ice crps nerve block crps

Ice, lidocaine patches, numbing creams, nerve blocks, ablations, opioids. When CRPS pain is severe, numbing the area is the first thing most people reach for, and the first thing most providers offer. Relief matters. Less time spent in pain is a good thing.

There is also a long-term cost to numbing that rarely gets explained at the appointment. With CRPS, strategies that numb the painful area can deepen the very brain changes that keep the pain going. Here is what is happening, and how to use pain relief strategically instead of letting it become the whole plan.

The Brain Change at the Center of CRPS

CRPS involves two big changes. The nerves in the painful region become overly reactive. And the brain loses its ability to correctly process sensory information from that body part, so it responds to nearly every message from the limb as if it were an emergency.

I describe that second change as a smudged map. The brain keeps an internal map of every body part. In CRPS, the map of the affected limb blurs. The brain can no longer read the signals clearly, so it defaults to protection.

What smudges the map? Immobilization. That can be physical immobilization, such as a boot, cast, brace, splint, or sleeve. It can also be functional immobilization: not using the limb, avoiding it, compensating, ignoring it, keeping it covered and out of mind. Over time the brain disconnects from the area. In some people the disconnect becomes so strong that the limb no longer feels like their own, and the body starts defending against it as if it were a foreign object, almost like rejecting a transplant.

Why Numbing Works Against You Long Term

Look at that list of causes again: avoiding, ignoring, neglecting, disconnecting. Numbing belongs on the same list.

When the goal is to stop feeling the area, the brain receives less information from the limb. Less information means a blurrier map and a deeper disconnect. The short-term result is relief. The long-term result can be a stronger version of the problem.

There is a second effect. The protective system in CRPS is trying to send you a message about potential danger. When that message is repeatedly shut down, the system does not quietly give up. The best way I can describe it is that the system says, "You keep trying to quiet me, so I am going to get louder." Protection ramps up. Sensitivity goes up. The underlying mechanism gets reinforced even while the pain is temporarily dulled.

The Strategies That Fall Into This Category

Each of these works by reducing what you feel from the area:

  • Ice numbs the tissue and the nerves beneath it.
  • Numbing creams and lidocaine patches dull sensation in the skin of the painful region.
  • Nerve blocks and injections interrupt signaling from the area for a period of time.
  • Ablations interrupt signaling from specific nerves for longer.
  • Opioid medications dull pain processing more broadly.

All of them can deliver real short-term relief. All of them can also feed back into the core problem of neurologic sensitivity (the process many medical settings call central sensitization) when they become the primary strategy.

This Is Not a Judgment

I am not the opioid police, and I have zero judgment about what you take or use to get through the day. Medication decisions belong to you and your prescriber.

What I want is for you to know what each strategy does to your condition over time, not only what it does to your pain this afternoon. That knowledge is what lets you make an informed decision instead of an automatic one.

There is real value in these strategies. The issue is how they are paired. When relief is used to make recovery work possible, it is strategic. When relief becomes the only work, the system keeps its reasons to stay sensitive, and you keep needing more relief.

What Reconnection Looks Like

If disconnection sharpens the problem, reconnection is the long-term direction. That means doing the opposite of avoidance and numbing, without forcing it. Pushing through pain will not help here either. The principle is to push to it, not through it.

In practice, reconnection uses methods that give the brain clear, tolerable information about the limb:

  • Sensory discrimination, where you identify and tell apart different non-painful sensations on the skin, so the brain reads the area accurately again.
  • Graded motor imagery, in sequence: left/right discrimination first, then explicit motor imagery, with mirror therapy last.
  • Paced movement, starting at your current tolerance and progressing based on how your system responds.

Desensitization is not on that list. It targets only allodynia and hyperalgesia, it is painful by design, and it works through accommodation, which can smudge the map further.

How to Use Pain Relief Strategically

For every numbing strategy in your current plan, ask:

  • Am I using this to make recovery work possible, or as a substitute for it?
  • Does it help me use the limb more, or does it let me ignore the limb longer?
  • Is my need for it holding steady, or climbing?

A useful pattern is to time relief so it opens a window. Use that window for a sensory discrimination session, a motor imagery block, or a short paced activity with the limb. That way relief supports reconnection instead of replacing it.

If you were told there is nothing left to try beyond the next injection, read "There Is No Cure for CRPS" Is a Prognosis, Not a Treatment Plan. "There's nothing more we can do" is not an evidence-based statement.

Want the full picture? Watch my free three-part CRPS series: what is actually happening in the nerves and brain, which treatments help and which cost you later, and what you can do about it.

Ready for a structured plan? The Uprising: Complex Pain Academy is built to address neurologic sensitivity in CRPS step by step, in the right order.

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Hi, I'm Dr. Alissa Wolfe

PT, DPT, OMPT, OCS, CHC, TPS

I'm a board-certified orthopedic doctor of physical therapy, but I specialize in complex and persistent pain.

My focus is on the neurologic wiring between the structures of the body and the mind — the missing piece most treatments overlook.

I've been building pain programs across the US since 2016 — including one for the US Army — because I kept seeing the same gap: smart, motivated people doing everything they were told, and still not getting better.

In 2021 I founded The Uprising: Complex Pain Academy to fill the gap the medical system has left wide open.

Now, I work exclusively with people who have complex pain that hasn't responded to standard treatments, providing the structure, guidance, and relief they've been searching for.

Learn about the Program